Amphetamine is a psychostimulant that acts on the dopaminergic system and increases dopamine release. Chronic exposure to this drug is reported to induce epigenetic changes, but the mechanisms underlying this phenomenon are unknown. My project is focused on understanding the effects of amphetamine exposure and decoding the mechanisms responsible for epigenetic changes. Because of these heritable changes, the alterations in transcriptomic levels will help to work out the pathway amphetamine uses to induce long-term effects. C. elegans is mostly used for these studies because of several conserved pathways across species. Moreover, the simplicity of the nervous system, particularly the dopaminergic system which is the main target of amphetamine, makes it a suitable model for this study.